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Meal Duration as a Measure of Orofacial Nociceptive Responses in Rodents
Published on: January 10, 2014
Neural mechanisms of nociception during orthodontic treatment
Masayuki Kobayashi1,2,3, Eri Horinuki1,4
1Department of Pharmacology, Nihon University School of Dentistry.
Abstract:
Orthodontic tooth movement is accompanied by inflammatory responses in the periodontal ligament. Chemical mediators such as interleukin-1β have key roles in nociception around teeth. Such nociceptive inputs to the periodontal ligament continue for several days and potentially induce plastic changes in higher brain regions, including the cerebral cortex. This review summarizes research on orthodontic treatment-induced modulation of neural activities in the central nervous system. Furthermore, we describe our recent findings on the spatiotemporal effects of orthodontic treatment in the somatosensory and insular cortices.
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