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ALLOGENEIC PLATELET-RICH PLASMA FOR ROTATOR CUFF REPAIR
Chris Hyunchul Jo1, Ji Sun Shin1, Seung Yeon Lee1
1. Seoul National University College of Medicine, SMG-SNU Boramae Medical Center, Department of Orthopedic Surgery, Seoul, Korea.
Acta Ortopedica Brasileira
|June 24, 2017
Summary
Allogeneic platelet-rich plasma (PRP) is safe for rotator cuff repair and shows efficacy comparable to autologous PRP. This study found no significant differences in clinical or structural outcomes between the two PRP types.
Area of Science:
- Orthopedic Surgery
- Regenerative Medicine
- Biomaterials
Background:
- Rotator cuff tears are common injuries requiring surgical repair.
- Platelet-rich plasma (PRP) is used to enhance healing.
- The safety and efficacy of allogeneic PRP in rotator cuff repair require further investigation.
Purpose of the Study:
- To evaluate the safety and efficacy of allogeneic PRP compared to autologous PRP in arthroscopic rotator cuff repair.
- To assess clinical and structural outcomes following rotator cuff repair with allogeneic PRP.
Main Methods:
- A comparative study involving 17 patients with full-thickness rotator cuff tears.
- Ten patients received arthroscopic rotator cuff repair with allogeneic PRP, and seven received autologous PRP.
- Clinical outcomes were assessed preoperatively and at a minimum 2-year follow-up; structural outcomes included retear rates and changes in supraspinatus cross-sectional area (ACT).
Main Results:
- Allogeneic PRP demonstrated no adverse events during the follow-up period.
- No significant differences were observed in clinical outcome measures between allogeneic and autologous PRP groups (p > 0.05).
- Retear rates (33.3% vs. 25.0%) and postoperative ACT changes were comparable between the groups (p = 0.764 and p = 0.373, respectively).
Conclusions:
- Allogeneic PRP is a safe option for arthroscopic rotator cuff repair, causing no local or general complications.
- The efficacy of allogeneic PRP is comparable to autologous PRP regarding both clinical and structural outcomes.
- Allogeneic PRP represents a viable alternative for enhancing rotator cuff repair.
