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Hormonal blockade modifies post-traumatic protein catabolism.

N Hulton, D J Johnson, R J Smith

    The Journal of Surgical Research
    |October 1, 1985
    PubMed
    Summary
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    Hormonal blockade after surgery reduces skeletal muscle protein breakdown but doesn't change overall nitrogen loss. This suggests other factors contribute to increased urea production post-injury.

    Area of Science:

    • Physiology
    • Endocrinology
    • Surgical Research

    Background:

    • Protein catabolism increases after injury, driven by stress hormones like cortisol and catecholamines.
    • Understanding hormonal influence is key to mitigating post-surgical metabolic stress.

    Purpose of the Study:

    • To investigate the impact of blocking catecholamine and cortisol effects on post-operative protein catabolism.
    • To determine if hormonal blockade alters skeletal muscle amino acid flux and nitrogen balance.

    Main Methods:

    • 16 dogs underwent abdominal surgery with catheter implantation.
    • Groups received either alpha- and beta-adrenergic blockade or high epidural anesthesia to block hormonal responses.
    • Hindquarter amino acid flux, muscle amino acid content, and urinary nitrogen excretion were measured.

    Related Experiment Videos

    Main Results:

    • Urinary creatinine excretion decreased in both treatment groups compared to controls.
    • Hindquarter amino acid nitrogen efflux was significantly reduced by hormonal blockade.
    • Neither blockade strategy prevented overall urinary nitrogen loss or muscle glutamine depletion.

    Conclusions:

    • Hormonal blockade effectively inhibits net skeletal muscle protein catabolism following surgery.
    • Whole-body nitrogen loss and increased ureagenesis post-injury are not solely mediated by catecholamines and cortisol.