Transition-Metal-Free C-H Hydroxylation of Carbonyl Compounds
Moreshwar B Chaudhari1, Yogesh Sutar1, Shreyas Malpathak1
1Department of Chemistry, Indian Institute of Science Education and Research , Pune 411008, India.
Abstract:
Transition metal and reductant free α-C(sp3)-H hydroxylation of carbonyl compounds are reported. This method is promoted by commercially available inexpensive KO-t-Bu and atmospheric air as an oxidant at room temperature. This unified strategy is also very facile for hydroxylation of various carbonyl compound derivatives to obtain quaternary hydroxyl compounds in excellent yield. A preliminary mechanistic investigation, supported by isotope labeling and computational studies, suggests the formation of a peroxide bond and its cleavage by in situ generated enolate.
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