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Related Concept Videos

The ABO Blood Group01:12

The ABO Blood Group

5.5K
The ABO blood group system is a critical element of transfusion medicine, essential for determining blood compatibility in transfusions and organ transplants. It is based on specific antigens, or agglutinogens, present on the surface of red blood cells (RBCs) and corresponding antibodies, or agglutinins, in the blood plasma.
Antigens in the ABO Blood Group System
Antigens are substances that can trigger an immune response, leading to the production of antibodies. In the ABO blood group system,...
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Blood Transfusion01:15

Blood Transfusion

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Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
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A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
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Blood Typing01:10

Blood Typing

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Understanding an individual's blood group is a critical component of transfusion medicine. It ensures compatibility in blood transfusions, organ transplants, and even during pregnancy. Determining these blood groups involves the ABO and Rh blood typing systems, utilizing specific antigens and corresponding anti-sera to identify an individual's blood type.
Antigens are protein molecules that reside on the surface of red blood cells (RBCs). The ABO and Rh blood typing systems target...
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Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

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Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
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Blood Types02:20

Blood Types

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Human blood is classified into different types based on the presence of antigens on the red blood cell's surface and antibodies in the plasma. Proper identification of blood type is essential for successful blood transfusion. The International Society of Blood Transfusion has identified 38 human blood types based on the surface antigens on the red blood cells. The most common types are ABO, Rh, and MNS blood types.
ABO blood group
ABO antigens are glycoproteins encoded by genes present on...
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Rh Blood Group01:19

Rh Blood Group

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The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
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Related Experiment Video

Updated: Feb 27, 2026

Detection of Residual Donor Erythroid Progenitor Cells after Hematopoietic Stem Cell Transplantation for Patients with Hemoglobinopathies
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Recognizing and resolving ABO discrepancies.

Geralyn M Meny1

  • 1Grifols Diagnos-tics, 3031 Panzano Place, San Antonio, TX.

Immunohematology
|June 29, 2017
PubMed
Summary
This summary is machine-generated.

ABO discrepancies occur when red blood cell (RBC) typing and plasma typing results conflict. This review covers causes, resolution strategies including molecular testing, and transfusion options for ABO discrepancies.

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Area of Science:

  • Transfusion Medicine
  • Clinical Laboratory Science
  • Immunology

Background:

  • Accurate ABO blood group determination is critical for safe transfusions.
  • ABO typing involves both forward (RBC antigen) and reverse (plasma antibody) testing.
  • Discrepancies between forward and reverse typing can lead to transfusion complications.

Purpose of the Study:

  • To review common causes of ABO discrepancies in transfusion services.
  • To present methods for resolving ABO typing discrepancies.
  • To discuss transfusion strategies for patients with ABO discrepancies.

Main Methods:

  • Review of literature on ABO discrepancies.
  • Analysis of causes and resolution techniques.
  • Presentation of case studies illustrating transfusion management.

Main Results:

  • Identified various causes of ABO discrepancies, such as weakened antigen expression or unexpected antibodies.
  • Outlined resolution pathways, including serological and molecular methods.
  • Demonstrated appropriate transfusion choices based on discrepancy type.

Conclusions:

  • ABO discrepancies require careful investigation and resolution to ensure patient safety.
  • Molecular testing offers a valuable tool for resolving complex ABO discrepancies.
  • Effective management of ABO discrepancies is essential in clinical transfusion practice.