Related Experiment Video
Updated: Feb 27, 2026
06:07
Cigarette Smoke Exposure in Mice using a Whole-Body Inhalation System
Published on: October 22, 2020
7.8K
Axial Spondyloarthritis and Cigarette Smoking
Irène Kona Kaut1,2, Fatima Ezzhara Abourazzak3, Essouri Jamila1,2
1Sidi Mohammeh Ben Abdellah University, Faculty of Medicine and Pharmacy, Fes, Morocco.
The Open Rheumatology Journal
|June 30, 2017
Summary
Smoking is linked to male sex and increased disease severity in axial spondyloarthritis patients. This finding highlights smoking as a significant risk factor impacting disease progression and patient outcomes.
Area of Science:
- Rheumatology
- Environmental Health
- Epidemiology
Background:
- Smoking is a key environmental risk factor for rheumatic diseases.
- The American College of Rheumatology (ACR 2014) identifies smoking as a risk factor for severe axial spondyloarthritis (axSpA).
Purpose of the Study:
- To investigate the association between smoking and disease activity.
- To examine the relationship between smoking and functional impact in axSpA patients.
- To assess the link between smoking and disease severity in axSpA.
Main Methods:
- A cross-sectional study was conducted between January 2014 and December 2015.
- Data from 214 patients with axSpA were analyzed using SPSS v20.
- Univariate, bivariate, and multivariate logistic regression analyses were performed with p < 0.005 significance.
Main Results:
- The prevalence of smoking among axSpA patients was 36%.
- Smoking was significantly associated with male sex (p≤0.0001), functional impairment (BASFI, p=0.038), and disease activity (BASDAI, p=0.004; ASDAS CRP, p=0.036).
- Multivariate analysis confirmed smoking's association with male sex and disease severity.
Conclusions:
- A significant association exists between smoking and male sex in axSpA.
- Smoking is significantly associated with increased disease severity in axial spondyloarthritis.
More Related Videos
Related Concept Videos
01:26Stress Prevention and Stress Management Techniques IV
288
Stress often leads to unhealthy habits like smoking, excessive drinking, and overeating, which offer short-term relief but ultimately increase long-term health risks. These behaviors create a cycle that temporarily lowers stress levels but can result in severe long-term health consequences. Breaking these habits is essential to reduce the risk of chronic diseases and improve overall well-being. Three primary changes that support better health include quitting smoking, reducing alcohol intake,...
288
01:11Genome-wide Association Studies-GWAS
16.0K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
16.0K
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
4.9K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
4.9K
01:20The JAK-STAT Signaling Pathway
13.4K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
13.4K
01:20COPD: Pathogenesis and Clinical Features
2.0K
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
2.0K
01:24Chronic Obstructive Pulmonary Disease
2.8K
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
2.8K