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Using speckle to measure tissue dispersion in optical coherence tomography
Christos Photiou1, Evgenia Bousi1, Ioanna Zouvani2
1KIOS Research Center, Department of Electrical and Computer Engineering, University of Cyprus, Nicosia, Cyprus.
Biomedical Optics Express
|July 1, 2017
Summary
A new method uses optical coherence tomography (OCT) speckle patterns to measure tissue dispersion, improving disease diagnosis. This technique successfully distinguished normal from cancerous colon tissues with 96% accuracy.
Area of Science:
- Biomedical Optics
- Medical Imaging
- Ophthalmology
Background:
- Optical coherence tomography (OCT) is a valuable imaging modality.
- Tissue dispersion is a potential biomarker for early disease detection.
- Current dispersion measurement methods for OCT are limited, especially for in vivo applications.
Purpose of the Study:
- To develop a novel in situ method for measuring dispersion using OCT.
- To assess the applicability of this technique for disease diagnosis.
Main Methods:
- A new technique was developed to estimate dispersion-induced resolution degradation from OCT image speckle.
- The method was validated experimentally using ex vivo samples.
- The technique was applied to classify normal and cancerous colon OCT images.
Main Results:
- The novel method is applicable in situ, overcoming limitations of previous techniques.
- Experimental validation confirmed the method's accuracy.
- Classification of colon OCT images achieved 96% accuracy in distinguishing normal from cancerous tissues.
Conclusions:
- The developed speckle-based dispersion measurement technique enhances OCT's diagnostic potential.
- This method offers a promising tool for in vivo disease detection and characterization.
- High accuracy in classifying colon tissues highlights its clinical relevance.
