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Production of Adeno-Associated Virus Vectors in Cell Stacks for Preclinical Studies in Large Animal Models
Published on: June 30, 2021
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Host determinants of adeno-associated viral vector entry
Sirika Pillay1, Jan E Carette1
1Stanford University, Department of Microbiology and Immunology, Stanford, CA 94305, USA.
Current Opinion in Virology
|July 4, 2017
Summary
Adeno-associated virus (AAV) vectors are crucial for gene therapy. This review details AAV entry mechanisms and host interactions, highlighting the AAV receptor (AAVR) and trafficking factors to improve gene delivery efficiency.
Area of Science:
- Molecular Biology
- Virology
- Gene Therapy
Background:
- Adeno-associated virus (AAV) vectors are promising tools for therapeutic gene delivery.
- Understanding the intricacies of AAV vector entry is essential for enhancing transduction efficiency and specificity.
Purpose of the Study:
- To review the current knowledge of adeno-associated virus (AAV) vector entry mechanisms.
- To discuss the roles of AAV receptors, attachment factors, and host factors in viral trafficking.
- To explore how technological advancements deepen the understanding of AAV-host interactions for improved gene delivery.
Main Methods:
- Comprehensive review of existing literature on AAV entry and trafficking.
- Discussion of identified AAV receptors, including the multi-serotype receptor AAVR.
- Analysis of host factors involved in retrograde transport from endosomes to the trans-Golgi network.
Main Results:
- Detailed overview of the AAV entry process, emphasizing key host-pathogen interactions.
- Identification and functional description of critical cellular receptors and attachment factors for AAV.
- Elucidation of host factors governing AAV vector trafficking within the cell.
Conclusions:
- A deeper understanding of AAV entry and trafficking pathways is critical for optimizing gene therapy vectors.
- The discovery of AAVR and insights into host factor utilization provide a foundation for rational vector design.
- Advances in genetic screening are significantly enhancing our comprehension of AAV-host interactions for nuclear delivery.
