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Updated: Feb 27, 2026
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An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma
Published on: April 17, 2013
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Noninvasive follicular thyroid neoplasm with papillary-like nuclear features
Abir A Ghuzlan1, Helton E Ramos, Martin Schlumberger
1Institut Gustave Roussy, Villejuif, France.
Summary
The encapsulated follicular variant of papillary thyroid cancer is now named noninvasive follicular thyroid neoplasm with papillary-like nuclear features. This renaming reflects its low malignant potential and supports less aggressive patient management.
Area of Science:
- Endocrinology
- Oncology
- Pathology
Background:
- The encapsulated follicular variant of papillary thyroid cancer (FVPTC) has historically been diagnosed based on thorough examination of tumor tissue and capsule.
- Exclusion of vascular or capsular invasion is critical for diagnosis.
Purpose of the Study:
- To provide an overview of the renaming of encapsulated FVPTC.
- To introduce the new nomenclature: noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP).
Main Methods:
- Review of recent retrospective studies on encapsulated FVPTC.
- Analysis of diagnostic criteria, including capsular and vascular invasion assessment.
Main Results:
- Excellent clinical outcomes observed in encapsulated FVPTC, characterized by extremely low malignant potential.
- The term "cancer" has been removed from the diagnosis due to its low-risk nature, indicating a need for less aggressive follow-up and treatment.
Conclusions:
- The renaming of encapsulated FVPTC to NIFTP acknowledges its low-risk status, aligning with previous conservative treatment approaches.
- Eliminating "cancer" from the diagnosis may reduce the psychological and social burden on patients.
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