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The decision to treat: profiling benefit.

C T Dollery

    Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension
    |November 1, 1985
    PubMed
    Summary
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    Treating hypertension requires personalized drug selection, moving beyond general risk factors. Individual patient characteristics significantly influence treatment benefits and potential adverse effects for better outcomes.

    Area of Science:

    • Cardiology
    • Pharmacology
    • Internal Medicine

    Background:

    • Hypertension treatment decisions traditionally rely on blood pressure levels and epidemiological risk factors.
    • An underlying assumption is uniform patient response to antihypertensive medications.

    Purpose of the Study:

    • To challenge the traditional risk factor-based approach in hypertension management.
    • To advocate for individualized treatment strategies based on potential patient benefits.

    Main Methods:

    • Review of recent evidence on factors influencing drug efficacy and safety.
    • Analysis of how patient-specific variables impact treatment outcomes.

    Main Results:

    • Patient benefits from antihypertensive drugs are modulated by age, sex, race, and smoking status.

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  • Pre-existing conditions like asthma, diabetes, and gout can be exacerbated by common medications.
  • Risk factor analysis alone is insufficient for optimal treatment decisions.

    • Conclusions:

    • Individualized assessment of potential benefits and risks is superior to traditional risk factor analysis for hypertension treatment.
    • Personalized medicine approaches are crucial for optimizing therapeutic outcomes in hypertensive patients.