Related Experiment Video
Updated: Feb 27, 2026

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
Published on: January 17, 2018
Skull base erosion and associated complications in sphenoid sinus fungal balls
Josh C Meier1, George A Scangas, Aaron K Remenschneider
1Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boson, Massachusetts, USA.
Background:
Sphenoid sinus fungal balls (SSFB) are rare entities that can result in serious orbital and intracranial complications. There are few published reports of complications that result from SSFB.
Objective:
To review the incidence of skull base erosion and orbital or intracranial complications in patients who present with SSFB.
Methods:
A retrospective review was performed of all the patients with SSFB who were treated at the Massachusetts Eye and Ear Infirmary from 2006 to 2014. Presenting clinical data, radiology, operative reports, pathology, and postoperative course were reviewed.
Results:
Forty-three patients with SSFB were identified. Demographic data were compared between patients with (39.5%) and those without (61.5%) skull base erosion. Two patients underwent emergent surgery for acute complications of SSFB (one patient with blindness, one patient who had a seizure). Both patients with acute complications had evidence of skull base erosion, whereas no patients with an intact skull base developed an orbital or intracranial complication (p = 0.15). All the patients were surgically managed via an endoscopic approach.
Conclusion:
SSFBs are rare but may cause significant skull base erosion and potentially severe orbital and intracranial complications if not treated appropriately. Endoscopic sphenoidotomy is effective in treating SSFB and should be performed emergently in patients who presented with associated complications.
Insights
Sphenoid sinus fungal balls (SSFB) can cause serious complications, including skull base erosion. Early endoscopic treatment is crucial for patients with SSFB, especially those with acute complications.
Area of Science:
- Otolaryngology
- Neurosurgery
- Infectious Diseases
Background:
- Sphenoid sinus fungal balls (SSFB) are uncommon but can lead to severe orbital and intracranial issues.
- Published reports on SSFB complications are limited.
Purpose of the Study:
- To determine the incidence of skull base erosion.
- To review orbital and intracranial complications in patients with SSFB.
Main Methods:
- Retrospective review of 43 patients with SSFB treated between 2006 and 2014.
- Analysis of clinical data, radiology, operative reports, pathology, and postoperative course.
Main Results:
- Skull base erosion was present in 39.5% of patients.
- Two patients experienced acute complications (blindness, seizure), both with skull base erosion.
- No patients with an intact skull base developed orbital or intracranial complications.
Conclusions:
- SSFBs, though rare, can cause significant skull base erosion and severe complications.
- Endoscopic sphenoidotomy is an effective treatment for SSFB.
- Emergent endoscopic intervention is recommended for SSFB patients with complications.
Related Concept Videos
Cranial Bones: Lateral View
The temporal bone forms the lower lateral side of the skull. The temporal bone is subdivided into several regions. The flattened upper portion is the squamous portion of the temporal bone. Below this area and projecting anteriorly is the zygomatic process of the temporal bone, which forms the posterior portion of the zygomatic arch. Posteriorly is the mastoid portion of the temporal bone. Projecting...
Cranial Bones: Superior and Posterior View
The frontal bone is the single bone that forms the forehead. At its anterior midline, between the eyebrows, there is a slight depression called the glabella. The frontal bone also forms the supraorbital margin of the orbit. Near the middle of this margin is the supraorbital foramen, the opening that provides passage for a sensory nerve to the forehead. The frontal bone is thickened just above each supraorbital margin,...
Sutures of the Skull
Sutures are immobile joints between adjacent bones of the skull. The narrow gap between the bones is filled with dense, fibrous connective tissue that unites the bones. The long sutures located between the skull bones are not straight but instead follow irregular, tightly twisting paths. These twisting lines tightly...
Overview of the Skull
The cranial vault surrounds and protects the brain and houses the middle and inner ear structures. This cavity is bounded superiorly by the rounded top of the skull, which...

