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Related Concept Videos

Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

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Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
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The high insolubility of some precipitates can result in an unfavorable relative supersaturation. This can lead to colloidal particles with a large surface-to-mass ratio, where adsorption is promoted. For instance, in the precipitation of silver chloride, silver ions are adsorbed on the surface of the colloidal particles, forming a primary layer. This layer attracts ions of opposite charge (such as nitrate ions), forming a diffuse secondary layer of adsorbed ions. This electric double layer...
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Various dissolution theories provide insight into the factors that influence the dissolution rate. Danckwerts' Model suggests that turbulence, rather than a stagnant layer, characterizes the dissolution medium at the solid-liquid interface. In this model, the agitated solvent contains macroscopic packets that move to the interface via eddy currents, facilitating the absorption and delivery of the drug to the bulk solution. The regular replenishment of solvent packets maintains the...
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Studying Dynamic Processes of Nano-sized Objects in Liquid using Scanning Transmission Electron Microscopy
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Aggregation dynamics of nanoparticles at solid-liquid interfaces.

Xuezeng Tian1, Haimei Zheng, Utkur Mirsaidov

  • 1Centre for BioImaging Sciences, Department of Biological Sciences, National University of Singapore, 117557, Singapore.

Nanoscale
|July 8, 2017
PubMed
Summary
This summary is machine-generated.

Solid surfaces temporarily immobilize nanoparticles (NPs) during aggregation, slowing their movement and assembly. Rotational motion becomes dominant in later stages of NP aggregate formation at interfaces.

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Area of Science:

  • Surface Science
  • Nanotechnology
  • Materials Science

Background:

  • Nanoparticle (NP) dynamics at solid-liquid interfaces are crucial for many processes.
  • Understanding how interfaces affect NP motion and interactions remains a challenge.

Purpose of the Study:

  • To directly observe gold nanoparticle (NP) movement and aggregation at solid-liquid interfaces.
  • To elucidate the influence of solid surfaces on NP dynamics and assembly.

Main Methods:

  • Utilized in situ liquid cell transmission electron microscopy (TEM).
  • Directly visualized gold NP behavior and aggregation dynamics.

Main Results:

  • Solid surfaces transiently pin NPs, dampening translational and rotational motion.
  • Surface pinning reduces NP movement and aggregation rates.
  • Translational motion is dampened more than rotational motion initially; rotational motion dominates later stages.

Conclusions:

  • Surface pinning significantly alters NP and aggregate dynamics at interfaces.
  • Insights into NP assembly control at interfaces for future applications.
  • Understanding NP motion differences (translational vs. rotational) is key for aggregate growth.