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Published on: August 16, 2018
Efficient and Mild Ullmann-Type N-Arylation of Amides, Carbamates, and Azoles in Water
Maud Bollenbach1, Pedro G V Aquino1,2, João Xavier de Araújo-Júnior2
1Université de Strasbourg, CNRS, LIT UMR 7200, 67000, Strasbourg, France.
Abstract:
A simple, sustainable, efficient, mild, and low-cost protocol was developed for d-glucose-assisted Cu-catalyzed Ullmann reactions in water for amides, carbamates, and nitrogen-containing heterocycles. The reaction was compatible with diverse aryl/heteroaryl iodides, giving highly substituted pyridine, indole, or indazole rings. This method offers an attractive alternative to existing protocols, because the reaction proceeds in aqueous media, occurs at or near ambient temperature, and provides the N-arylated products in good to high yields.
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