Search research articles

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Use of interactive mathematical simulations in Fundamentals of Biochemistry, a LibreText online educational resource, to promote understanding of dynamic reactions.

Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology·2024

Same author

Intra-cardiac transfer of fatty acids from capillary to cardiomyocyte.

PloS one·2022

Same author

Equations for O<sub>2</sub> and CO<sub>2</sub> solubilities in saline and plasma: combining temperature and density dependences.

Journal of applied physiology (Bethesda, Md. : 1985)·2017

Same author

Understanding the physiology of the ageing individual: computational modelling of changes in metabolism and endurance.

Interface focus·2016

Same author

The Pathway for Oxygen: Tutorial Modelling on Oxygen Transport from Air to Mitochondrion: The Pathway for Oxygen.

Advances in experimental medicine and biology·2016

Same author

Modeling Fatty Acid Transfer from Artery to Cardiomyocyte.

PLoS computational biology·2015

Same journal

Sentiment Analysis of Acceptance TVET Online Courses on the Skill Academy App from Google Play: Leveraging Text Mining with Comparison Machine Learning Model.

F1000Research·2026

Same journal

Emotional intelligence: An important skill to learn now more than ever.

F1000Research·2026

Same journal

East Mediterranean Lineage of <i>Brucella melitensis</i> in Human Isolates and Milk Samples in Oman Using MLVA-14.

F1000Research·2026

Same journal

Application of K-Means Clustering for Job Applicant Analysis in Construction Firms Using R.

F1000Research·2026

Same journal

The influence of self-esteem and emotional intelligence on addiction to social networks in Peruvian university students.

F1000Research·2026

Same journal

A Bibliometric Analysis of Music's Role in Promoting Well-Being in Health Science Research.

F1000Research·2026

See all related articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Feb 26, 2026

Construction of a Human Aorta Smooth Muscle Cell Organ-On-A-Chip Model for Recapitulating Biomechanical Strain in the Aortic Wall

Construction of a Human Aorta Smooth Muscle Cell Organ-On-A-Chip Model for Recapitulating Biomechanical Strain in the Aortic Wall

Published on: July 6, 2022

Semi-automated Modular Program Constructor for physiological modeling: Building cell and organ models.

Bartholomew Jardine¹, Gary M Raymond¹, James B Bassingthwaighte¹

¹Department of Bioengineering, University of Washington, Seattle, WA, 98195, USA.

|July 18, 2017

Summary

This summary is machine-generated.

The Modular Program Constructor (MPC) simplifies complex physiological modeling by automatically generating code from existing modules. This open-source Java tool accelerates multi-scale model development and hypothesis testing.

Keywords:

JSim multi-scale modeling physiological modeling reproducibility systems biology uncertainty quantification

More Related Videos

Creating a Structurally Realistic Finite Element Geometric Model of a Cardiomyocyte to Study the Role of Cellular Architecture in Cardiomyocyte Systems Biology

Creating a Structurally Realistic Finite Element Geometric Model of a Cardiomyocyte to Study the Role of Cellular Architecture in Cardiomyocyte Systems Biology

Published on: April 18, 2018

Manipulating Living Cells to Construct Stable 3D Cellular Assembly Without Artificial Scaffold

Manipulating Living Cells to Construct Stable 3D Cellular Assembly Without Artificial Scaffold

Published on: October 26, 2018

Related Experiment Videos

Last Updated: Feb 26, 2026

Construction of a Human Aorta Smooth Muscle Cell Organ-On-A-Chip Model for Recapitulating Biomechanical Strain in the Aortic Wall

Construction of a Human Aorta Smooth Muscle Cell Organ-On-A-Chip Model for Recapitulating Biomechanical Strain in the Aortic Wall

Published on: July 6, 2022

Creating a Structurally Realistic Finite Element Geometric Model of a Cardiomyocyte to Study the Role of Cellular Architecture in Cardiomyocyte Systems Biology

Creating a Structurally Realistic Finite Element Geometric Model of a Cardiomyocyte to Study the Role of Cellular Architecture in Cardiomyocyte Systems Biology

Published on: April 18, 2018

Manipulating Living Cells to Construct Stable 3D Cellular Assembly Without Artificial Scaffold

Manipulating Living Cells to Construct Stable 3D Cellular Assembly Without Artificial Scaffold

Published on: October 26, 2018

Area of Science:

Computational Biology
Systems Biology
Physiological Modeling

Background:

Developing complex physiological models is time-consuming due to the myriad simultaneous processes in biological systems.
Manual model combination is error-prone and inefficient, hindering rapid hypothesis testing and multi-scale research.

Purpose of the Study:

To introduce the Modular Program Constructor (MPC), an open-source Java utility designed to streamline the construction of complex physiological models.
To provide a method for rapidly assembling and testing multi-scale models by automating code generation from modular components.

Main Methods:

MPC utilizes JSim's Mathematical Modeling Language (MML) and embedded directives to construct larger models from smaller, existing ones.
Code-generating algorithms within MPC take input from multiple models to produce new JSim-compatible model code.
The system encodes and preserves module relationships, facilitating easy updates and substitutions for hypothesis testing.

Main Results:

MPC significantly reduces the time and errors associated with building complex physiological models.
The tool enables efficient multi-scale model development, allowing for rapid configuration and testing of numerous variants.
Preservation of module information supports iterative refinement and hypothesis-driven model modification.

Conclusions:

MPC offers a powerful, open-source solution for accelerating physiological model development and multi-scale research.
The utility enhances the efficiency and accuracy of creating complex biological simulations by automating model assembly.
MPC facilitates hypothesis testing by enabling quick module substitution and model variant management.