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Is endothelin gene polymorphism associated with postoperative atrial fibrillation in patients undergoing coronary

Ira Dhawan1, Minati Choudhury1, Milind P Hote2

  • 1Department of Cardiac Anaesthesia, Cardiothoracic Sciences Centre, New Delhi, India.

Annals of Cardiac Anaesthesia
|July 14, 2017
PubMed

Insights

Genetic variations in the endothelin-1 (ET-1) gene and higher plasma ET-1 levels are linked to atrial fibrillation (AF) in patients undergoing coronary artery bypass grafting (CABG). The Lys198Asn (G/T) single nucleotide polymorphism (SNP) showed significant differences between AF+ and AF- groups.

Area of Science:

  • Cardiovascular Genetics
  • Molecular Cardiology
  • Surgical Outcomes Research

Background:

  • Atrial fibrillation (AF) is a common complication after coronary artery bypass grafting (CABG), with multifactorial causes.
  • Existing prophylactic measures have not fully reduced AF incidence in CABG patients.
  • The pro-arrhythmogenic role of endothelin-1 (ET-1) and its genetic associations warrant investigation.

Purpose of the Study:

  • To explore the association between plasma ET-1 concentrations and ET-1 gene polymorphisms with AF occurrence in CABG patients.
  • To investigate specific ET-1 gene single nucleotide polymorphisms (SNPs): -1370 T/G, -134 (3A/4A) Ins/del, and Lys198Asn (G/T).

Main Methods:

  • Genotyping of 98 non-diabetic patients undergoing CABG for three ET-1 gene SNPs using gene sequencing.
  • Measurement of plasma ET-1 concentrations via ET immunoassay.
  • Comparison of allele frequencies and plasma ET-1 levels between patients with and without AF post-CABG.

Main Results:

  • Plasma ET-1 concentrations were significantly higher in the AF+ group compared to the AF- group (P = 0.001).
  • Significant differences in allele frequencies were observed for the Lys198Asn (G/T) SNP of the ET-1 gene between AF+ and AF- groups.
  • No significant differences were found for the -1370 T/G and -134 (3A/4A) Ins/del SNPs.

Conclusions:

  • The ET-1 gene, particularly the Lys198Asn polymorphism, may play a role in the development of AF in the Indian CABG population.
  • Elevated ET-1 levels and specific genetic variations could be disease modifiers for AF post-CABG.
  • Further research is needed to elucidate the precise mechanisms linking ET-1 to post-CABG AF.
Abstract

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