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Related Experiment Video

Updated: Feb 26, 2026

Implantation of Total Artificial Heart in Congenital Heart Disease
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The OregonHeart Total Artificial Heart: Design and Performance on a Mock Circulatory Loop.

Jeremy Glynn1, Howard Song2, Bryan Hull1

  • 1Biomedical Engineering, OregonHeart, Inc., Roseville, CA, USA.

Artificial Organs
|July 14, 2017
PubMed
Summary

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A novel total artificial heart (TAH) using a shuttling rotor provides pulsatile blood flow without valves. This TAH prototype successfully maintained cardiac output under simulated pulmonary hypertension in vitro testing.

Area of Science:

  • Biomedical Engineering
  • Cardiovascular Research

Background:

  • Heart transplantation is limited by donor organ scarcity.
  • Total artificial hearts (TAHs) are crucial for biventricular support.
  • Existing TAH designs face challenges in replicating natural cardiac function.

Purpose of the Study:

  • To introduce a novel total artificial heart (TAH) design.
  • To evaluate the TAH's ability to provide pulsatile, valve-less blood flow.
  • To assess TAH performance under simulated physiological and pathophysiological conditions.

Main Methods:

  • Developed a TAH with a shuttling rotor for alternating systemic and pulmonary circulation.
  • Controlled flow rates and pressures via rotor speed, cycle frequency, and pumping proportion.
  • Validated the TAH prototype in a mock circulatory loop simulating various vascular conditions.
Keywords:
-Mechanical circulatory support-Mock circulatory loopTotal artificial heart

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Related Experiment Videos

Last Updated: Feb 26, 2026

Implantation of Total Artificial Heart in Congenital Heart Disease
07:27

Implantation of Total Artificial Heart in Congenital Heart Disease

Published on: July 18, 2014

25.3K
Implantation of the Syncardia Total Artificial Heart
16:11

Implantation of the Syncardia Total Artificial Heart

Published on: July 18, 2014

36.1K
An Isolated Working Heart System for Large Animal Models
09:45

An Isolated Working Heart System for Large Animal Models

Published on: June 11, 2014

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Main Results:

  • The TAH achieved a nominal output of 7.4 L/min at 120/80 mm Hg systemic pressure.
  • Maintained normal pulmonary artery and atrial pressures.
  • Sustained cardiac output during simulated pulmonary hypertension (7.5 Wood units) by adjusting pump speed.

Conclusions:

  • The novel shuttling TAH design is a viable proof-of-concept.
  • The TAH effectively maintains cardiac output across diverse pathophysiological states.
  • This valve-less TAH design shows promise for addressing donor organ scarcity in heart failure treatment.