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TiO2 -coated fluoride nanoparticles for dental multimodal optical imaging
Ana K S Braz1,2, Diógenes S Moura1,3, Anderson S L Gomes4
1Laboratory of Biomedical Optics and Imaging, Federal University of Pernambuco, Recife, Pernambuco, Brazil.
Journal of Biophotonics
|July 14, 2017
Summary
Novel core-shell nanoparticles enhance dental imaging. The TiO2 shell improves optical coherence tomography contrast, while the rare-earth core enables photoluminescence imaging for detailed dental adhesion evaluation.
Area of Science:
- Nanomaterials Science
- Biomedical Optics
- Dental Materials
Background:
- Core-shell nanostructures are vital in photonics for diagnostics and therapy.
- Optical imaging techniques offer non-invasive methods for evaluating dental materials and structures.
Purpose of the Study:
- To develop a novel core-shell nanostructure for multimodal optical imaging.
- To assess its efficacy as a contrast agent for dental adhesion evaluation.
Main Methods:
- Synthesized rare-earth-doped NaYF4 core/TiO2 shell nanoparticles (~66 nm).
- Utilized optical coherence tomography (OCT) and photoluminescence (PL) imaging.
- Incorporated nanoparticles into dental primer for adhesion layer visualization.
Main Results:
- TiO2 shell enhanced OCT contrast by increasing scattering coefficient by 67%.
- Rare-earth core provided upconversion photoluminescence at 800 nm from 975 nm excitation.
- Successfully visualized human tooth structures and dental adhesive layers using multimodal imaging.
Conclusions:
- The developed core-shell nanoparticles serve as an effective multimodal contrast agent for dental applications.
- This technology offers improved visualization of dental adhesion and deep tissue imaging.
