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[Hypertension]
Michel Burnier1, Grégoire Wuerzner1
1Service de néphrologie et hypertension, CHUV, 1011 Lausanne.
Revue Medicale Suisse
|July 14, 2017
Summary
The SPRINT trial recommended a systolic blood pressure target of <120 mmHg for high-risk patients. Criticisms may limit its application, while hypertension screening in youth and uric acid drugs for hypertensive patients are also discussed.
Area of Science:
- Cardiology
- Nephrology
- Public Health
Background:
- The Systolic Blood Pressure Intervention Trial (SPRINT) trial established a new target for hypertension management.
- High cardiovascular risk patients were the focus of the SPRINT trial's intensive blood pressure reduction strategy.
Purpose of the Study:
- To review the impact and criticisms of the SPRINT trial.
- To discuss hypertension screening in pediatric populations.
- To explore the role of uric acid-lowering drugs in hypertensive patients with hyperuricemia.
Main Methods:
- Literature review of the SPRINT trial and related publications.
- Analysis of criticisms and potential limitations of the SPRINT trial's findings.
- Review of current guidelines and research on pediatric hypertension and hyperuricemia management.
Main Results:
- The SPRINT trial's findings have significantly influenced hypertension treatment guidelines.
- Criticisms regarding the SPRINT trial's methodology and applicability have emerged.
- Further research is needed to clarify the role of uric acid-lowering drugs in specific hypertensive patient groups.
Conclusions:
- The SPRINT trial's <120 mmHg systolic blood pressure target, while influential, faces practical application challenges due to criticisms.
- Hypertension screening in children and adolescents requires further investigation.
- The therapeutic potential of uric acid-lowering agents in hypertensive patients with hyperuricemia warrants additional study.
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