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[Chromosomal aberrations in a subfertile cotton-top tamarin]
A Pieńkowska-Schelling1, F Wyss2, A Baumeyer2
1Institut für Genetik, Vetsuisse-Fakultät, Universität Bern.
Schweizer Archiv Fur Tierheilkunde
|July 14, 2017
Summary
A cotton-top tamarin exhibited ambiguous genitalia and reproductive issues, leading to suspected disorder of sexual development (DSD). Chromosomal analysis revealed mixed cell lines, complicating diagnosis due to the species
Area of Science:
- Primate reproductive biology
- Genetics and cytogenetics
- Veterinary medicine
Background:
- A female cotton-top tamarin presented with behavioral changes, ambiguous genitalia, and infertility.
- These clinical signs prompted suspicion of a disorder of sexual development (DSD).
Purpose of the Study:
- To investigate the underlying cause of the reproductive and developmental abnormalities in the cotton-top tamarin.
- To analyze the chromosomal makeup of the affected animal.
Main Methods:
- Karyotyping was performed on six cell lines from the tamarin.
- Analysis focused on identifying chromosomal abnormalities and mosaicism.
Main Results:
- The tamarin displayed multiple cell lines with varying karyotypes, including 46,XX and 46,XY.
- Less frequent cell lines showed numerical aberrations and a marker chromosome.
- The presence of chimerism and natural twinning in Callitrichidae complicated the interpretation.
Conclusions:
- The complex karyotype, influenced by species-specific traits like chimerism, hindered definitive diagnosis and prognosis for fertility.
- Further investigation is needed to understand DSD in this species.
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