Quantitative detection of glucose level based on radiofrequency patch biosensor combined with volume-fixed...

Area of Science:

• Biomedical Engineering
• Sensor Technology
• Analytical Chemistry

Background:

• Accurate and timely glucose monitoring is crucial for diabetes management.
• Existing glucose monitoring methods face challenges with precision and sample interference.
• Development of non-invasive or minimally invasive biosensors is an active research area.

Purpose of the Study:

• To present a concept for a radiofrequency (RF) patch biosensor for glucose level monitoring.
• To characterize the performance of two types of RF patch biosensors with integrated volume-fixed structures.
• To evaluate the biosensors' sensitivity, detection limits, response time, and reusability for glucose detection.

Main Methods:

• Development of two RF patch biosensor designs with distinct volume-fixed structures (0.53μL backside slot and 0.70μL front-side tank).
• Application of glucose analytes at varying concentrations (50-600mg/dL) to the biosensors.
• Measurement of changes in resonance frequency and reflection coefficient magnitude due to glucose interaction with the RF electromagnetic field.

Main Results:

• Both biosensor types exhibited high sensitivity (up to 1.97MHz/mg/dL) and low detection limits (as low as 15.22mg/dL).
• A rapid response time of less than 1 second was achieved.
• Excellent reusability was confirmed over multiple measurement cycles.
• Linear correlations were observed between glucose concentration and both resonance frequency shift and reflection coefficient magnitude.

Conclusions:

• The proposed RF patch biosensor with volume-fixed structures offers a sensitive, rapid, and reusable method for glucose detection.
• This technology shows potential for distinguishing glucose solution levels and early-stage detection in diabetes patients.
• The approach effectively minimizes interference from sample properties like liquidity, shape, and thickness.