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Related Experiment Video

Updated: Feb 26, 2026

Author Spotlight: Investigating the Relationship Between FSH and Pathophysiological Changes in Perimenopausal Women - Insights from a Mouse Model

Author Spotlight: Investigating the Relationship Between FSH and Pathophysiological Changes in Perimenopausal Women - Insights from a Mouse Model

Published on: August 11, 2023

Serum Fetuin-A Levels and Thyroid Function inMiddle-aged and Elderly Chinese.

Xin Ru Deng¹, Lin Ding¹, Tian Ge Wang¹

¹State Key Laboratory of Medical Genomics, Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, National Clinical Research Center for Metabolic Diseases, Collaborative Innovation Center of Systems Biomedicine, and Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai 200025, China; Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China.

Biomedical and Environmental Sciences : BES

|July 15, 2017

Summary

This summary is machine-generated.

Serum fetuin-A levels are linked to thyroid function. Higher free triiodothyronine and free thyroxine correlate with increased fetuin-A, suggesting a role in thyroid health.

Related Experiment Videos

Last Updated: Feb 26, 2026

Author Spotlight: Investigating the Relationship Between FSH and Pathophysiological Changes in Perimenopausal Women - Insights from a Mouse Model

Author Spotlight: Investigating the Relationship Between FSH and Pathophysiological Changes in Perimenopausal Women - Insights from a Mouse Model

Published on: August 11, 2023

Area of Science:

Endocrinology
Epidemiology
Biochemistry

Background:

Serum fetuin-A is reportedly elevated in hyperthyroidism.
Limited epidemiologic data exists on fetuin-A and thyroid function.

Purpose of the Study:

Investigate the association between serum fetuin-A concentrations and thyroid function.
Examine the relationship in an aging Chinese population.

Main Methods:

Cross-sectional study in Songnan community, China (2009).
Analysis of 2,984 participants aged 40+ years.
Multivariable linear regression and logistic regression analyses.

Main Results:

Serum fetuin-A positively associated with free triiodothyronine (FT3) and inversely with thyroid peroxidase antibody (TPOAb).
Higher tertiles of FT3 and free thyroxine (FT4) showed increased fetuin-A concentrations.
High serum fetuin-A linked to high thyroid function (OR 1.27, 95% CI 1.01-1.61).

Conclusions:

Serum fetuin-A concentrations are associated with thyroid function markers.
Findings suggest a potential role for fetuin-A in thyroid physiology and dysfunction.