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Updated: Feb 26, 2026

Flow Cytometry Analysis of Immune Cells Within Murine Aortas
Published on: July 1, 2011
Effects of Interleukin 17 on the cardiovascular system
Marie Robert1, Pierre Miossec1
1Immunogenomics and Inflammation Research Unit, EA 4130, Department of Immunology and Rheumatology, University of Lyon, Lyon, France.
Abstract:
Cardiovascular diseases remain the leading cause of death worldwide and account for most of the premature mortality observed in chronic inflammatory diseases. Common mechanisms underlie these two types of disorders, where the contribution of Interleukin (IL)-17A, the founding member of the IL-17 family, is highly suspected. While the local effects of IL-17A in inflammatory disorders have been well described, those on the cardiovascular system remain less studied. This review focuses on the effects of IL-17 on the cardiovascular system both on isolated cells and in vivo. IL-17A acts on vessel and cardiac cells, leading to inflammation, coagulation and thrombosis. In vivo and clinical studies have shown its involvement in the pathogenesis of cardiovascular diseases including atherosclerosis and myocardial infarction that occur prematurely in chronic inflammatory disorders. As new therapeutic approaches are targeting the IL-17 pathway, this review should help to better understand their positive and negative outcomes on the cardio-vascular system.
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