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Monitoring In-Vivo the Mammary Gland Microstructure during Morphogenesis from Lactation to Post-Weaning Using

Noam Nissan1,2, Edna Furman-Haran3, Myra Shapiro-Feinberg4

  • 1Department of Biological Regulation, Weizmann Institute of Science, P.O. Box 26, 7610001, Rehovot, Israel.

Journal of Mammary Gland Biology and Neoplasia
|July 15, 2017
PubMed
Summary

Magnetic Resonance Imaging (MRI) tracks mammary gland changes during lactation and post-weaning. This non-invasive technique differentiates tissue involution, aiding breast disorder diagnosis.

Keywords:
Diffusion Tensor ImagingLactating breast structureMagnetic Resonance ImagingMammary gland microstructure trackingPost-weaning breast structure

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Area of Science:

  • Biomedical Imaging
  • Radiology
  • Women's Health

Background:

  • Hormonal changes during lactation and post-weaning alter mammary gland microstructure.
  • These physiological changes complicate radiological assessment of breast disorders.
  • Pregnancy-associated breast cancer (PABC) poses diagnostic challenges during these periods.

Purpose of the Study:

  • To develop and validate non-invasive MRI protocols for in vivo mammary gland imaging.
  • To track anatomical and microstructural changes from lactation to post-weaning.
  • To quantitatively distinguish between lactation-induced tissue distention and post-weaning involution.

Main Methods:

  • High spatial resolution, T2-weighted MRI sequences were employed.
  • Diffusion Tensor Imaging (DTI) was utilized to assess tissue microstructure.
  • Advanced image processing tools were applied to analyze imaging data.

Main Results:

  • MRI protocols successfully captured in vivo images of the entire mammary gland.
  • DTI quantitatively differentiated ductal/glandular tissue distention during lactation from involution post-weaning.
  • T2-weighted imaging and DTI proved safe and non-invasive, relying on intrinsic tissue contrast.

Conclusions:

  • Non-invasive MRI, particularly DTI, can monitor mammary gland developmental stages.
  • This imaging approach aids in distinguishing physiological changes from potential pathologies.
  • The study provides a foundation for improved diagnosis in conditions like PABC.