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Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
Published on: February 6, 2020
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Sequential dynamic structuralisation by in situ production of supramolecular building blocks
Hirohiko Yuasa1, Kouichi Asakura1, Taisuke Banno1
1Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama, 223-8522, Japan. banno@applc.keio.ac.jp.
Chemical Communications (Cambridge, England)
|July 15, 2017
Summary
Researchers observed disordered droplets dynamically self-assemble into higher-ordered structures, forming a hydrogel. This process offers a model for understanding how complex biological systems develop from simpler components.
Area of Science:
- Supramolecular chemistry
- Materials science
- Biophysics
Background:
- Complex biological systems exhibit hierarchical structures.
- Understanding the self-assembly of disordered matter is crucial for biomimicry.
Purpose of the Study:
- To demonstrate sequential dynamic higher structuralisation from disordered droplets.
- To form a hydrogel through a self-assembly process.
- To provide a model for understanding biosystem development.
Main Methods:
- Dynamic self-assembly of disordered droplets.
- Hydrogel formation via structuralisation.
Main Results:
- Achieved sequential dynamic higher structuralisation.
- Successfully formed a hydrogel from disordered droplets.
- Demonstrated a transition from lower-ordered to higher-ordered structures.
Conclusions:
- The study presents a novel example of dynamic structuralisation leading to hydrogel formation.
- This process serves as a potential model for understanding the evolution of complex biosystems.
- The findings highlight the importance of self-assembly in creating functional higher-ordered structures from disordered precursors.
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