Average glandular dose coefficients for pendant-geometry breast CT using realistic breast phantoms

To design volume-specific breast phantoms from breast CT (bCT) data sets and estimate the associated normalized mean glandular dose coefficients for breast CT using Monte Carlo methods.

A large cohort of bCT data sets (N = 215) was used to evaluate breast volume into quintiles (plus the top 5%). The average radius profile was then determined for each of the six volume-specific groups and used to both fabricate physical phantoms and generate mathematical phantoms (V1-V6; "V" denotes classification by volume). The MCNP6 Monte Carlo code was used to model a prototype bCT system fabricated at our institution; and this model was validated against physical measurements in the fabricated phantoms. The mathematical phantoms were used to simulate normalized mean glandular dose coefficients for both monoenergetic source photons "DgN_CT (E)" (8-70 keV in 1 keV intervals) and polyenergetic x-ray beams "pDgN_CT " (35-70 kV in 1 kV intervals). The Monte Carlo code was used to study the influence of breast size (V1 vs. V5) and glandular fraction (6.4% vs. 45.8%) on glandular dose. The pDgN_CT coefficients estimated for the V1, V3, and V5 phantoms were also compared to those generated using simple, cylindrical phantoms with equivalent volume and two geometrical constraints including; (a) cylinder radius determined at the breast phantom chest wall "R_cw "; and (b) cylinder radius determined at the breast phantom center-of-mass "R_COM ".

Satisfactory agreement was observed for dose estimations using MCNP6 compared with both physical measurements in the V1, V3, and V5 phantoms (R² = 0.995) and reference bCT dose coefficients using simple phantoms (R² = 0.999). For a 49 kV spectrum with 1.5 mm Al filtration, differences in glandular fraction [6.5% (5th percentile) vs. 45.8% (95th percentile)] had a 13.2% influence on pDgN_CT for the V3 phantom, and differences in breast size (V1 vs. V5) had a 16.6% influence on pDgN_CT for a breast composed of 17% (median) fibroglandular tissue. For cylindrical phantoms with a radius of R_COM , the differences were 1.5%, 0.1%, and 2.1% compared with the V1, V3, and V5 phantoms, respectively.

Breast phantoms were designed using a large cohort of bCT data sets across a range of six breast sizes. These phantoms were then fabricated and used for the estimation of glandular dose in breast CT. The mathematical phantoms and associated glandular dose coefficients for a range of breast sizes (V1-V6) and glandular fractions (5th to 95th percentiles) are available for interested users.