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Updated: Feb 26, 2026

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
Published on: February 6, 2020
High fidelity sorting of remarkably similar components via metal-mediated assembly
Lauren R Holloway1, Michael C Young1, Gregory J O Beran1
1University of California - Riverside , Department of Chemistry , Riverside , CA 92521 , USA .
Abstract:
Subtle differences in ligand coordination angle and rigidity lead to high fidelity sorting between individual components displaying identical coordination motifs upon metal-mediated self-assembly. Narcissistic self-sorting can be achieved between highly similar ligands that vary minimally in rigidity and internal coordination angle upon combination with Fe(ii) ions and 2-formylpyridine. Selective, sequential cage formation can be precisely controlled in a single flask from a mix of three different core ligands (and 33 total components) differing only in the hybridization of one group that is uninvolved in the metal coordination process.
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