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In Situ Monitoring of Diffusion of Guest Molecules in Porous Media Using Electron Paramagnetic Resonance Imaging
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In Situ Monitoring of Diffusion of Guest Molecules in Porous Media Using Electron Paramagnetic Resonance Imaging

Published on: September 2, 2016

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Pulse wave analysis with diffusing-wave spectroscopy

Markus Belau1, Wolfgang Scheffer1, Georg Maret1

  • 1Universität Konstanz, Fachbereich Physik, 78457 Konstanz, Germany.

Biomedical Optics Express
|July 19, 2017
PubMed

Insights

This study introduces Diffusing Wave Spectroscopy (DWS) as a novel, non-invasive tool to monitor blood flow changes. DWS provides detailed pulse wave analysis, complementing traditional blood pressure measurements for hypertension management.

Area of Science:

  • Cardiovascular Science
  • Biomedical Engineering
  • Medical Diagnostics

Background:

  • Hypertension is a primary risk factor for cardiovascular disease, leading to significant mortality from events like heart attack and stroke.
  • Increased arterial stiffness, altered pulse wave velocity, and wave reflections contribute to hypertension, elevating left ventricular load and damaging microcirculation.
  • Current hypertension management relies on brachial cuff sphygmomanometry, but pulse wave analysis is needed for targeted treatment.

Purpose of the Study:

  • To introduce and evaluate Diffusing Wave Spectroscopy (DWS) as a novel non-invasive tool for monitoring blood flow dynamics.
  • To demonstrate DWS's capability in providing high temporal resolution data for pulse wave analysis.
  • To assess the utility of DWS in complementing traditional blood pressure measurements for a comprehensive understanding of hypertension.

Main Methods:

  • Utilized Diffusing Wave Spectroscopy (DWS), a novel non-invasive portable technology.
  • Measured pulse travel times to analyze blood flow characteristics.
  • Compared DWS data with conventional methods for assessing cardiovascular parameters.

Main Results:

  • Diffusing Wave Spectroscopy (DWS) demonstrated the ability to monitor blood flow changes with high temporal resolution.
  • The tool successfully captured detailed information regarding the pulse wave blood flow profile through measured pulse travel times.
  • DWS offers a promising non-invasive method for advanced cardiovascular assessment.

Conclusions:

  • Diffusing Wave Spectroscopy is a viable non-invasive technology for monitoring blood flow and pulse wave characteristics.
  • DWS provides valuable data for pulse wave analysis, complementing traditional hypertension measurements.
  • This novel tool has the potential to enhance the understanding and management of hypertension and related cardiovascular conditions.

Keywords:
(170.0170) Medical optics and biotechnology(170.1610) Clinical applications(170.3880) Medical and biological imaging(170.6480) Spectroscopy, speckle

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