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Oxidation-induced modification of the fibrinogen polypeptide chains

A V Bychkova1, A D Vasilyeva2, A E Bugrova2

  • 1Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, Russia. anna.v.bychkova@gmail.com.

Doklady. Biochemistry and Biophysics
|July 21, 2017
PubMed
Summary

Oxidation of fibrinogen affects its Aα, Bβ, and γ chains, with the αC-region being most vulnerable. These oxidative modifications inhibit protofibril aggregation, suggesting antioxidant roles for modified residues.

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