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FORMULATION AND TECHNOLOGY DEVELOPMENT OF HERBAL PHENOLIC BIOPOLYMER-CONTAINING FILMS FOR BURN TREATMENT
S Gokadze1, V Barbakadze1, K Mulkijanyan1
1Tbilisi State Medical University, Georgia.
Georgian Medical News
|July 21, 2017
Summary
New biosoluble phytofilms derived from comfrey (poly[3-(3,4-dihydroxyphenyl) glyceric acid] or PDGA) show promise for burn treatment. These natural films offer antimicrobial and anti-inflammatory benefits without irritation, providing an effective alternative to synthetic drugs.
Area of Science:
- Pharmaceutical Technology
- Natural Product Chemistry
- Dermatology
Background:
- Biosoluble phytofilms offer a promising approach to burn treatment due to their natural origin and reduced toxicity.
- Herbal remedies possess unique properties, including efficacy against antibiotic-resistant microbes and viruses, alongside analgesic and anti-inflammatory effects.
- Poly[3-(3,4-dihydroxyphenyl) glyceric acid] (PDGA), a novel phenolic biopolymer from comfrey, exhibits characteristics suitable for advanced wound healing applications.
Purpose of the Study:
- To develop a formulation and manufacturing technology for biosoluble phytofilms for burn treatment utilizing PDGA.
- To optimize the composition and properties of PDGA-based phytofilms for enhanced burn healing efficacy.
- To evaluate the impact of film-forming agents on the quality, adhesion, and moisture absorption of the developed phytofilms.
Main Methods:
- Biopharmaceutical studies were conducted to determine the optimal phytofilm content for burn healing.
- The influence of various film-formers on phytofilm characteristics, including quality, adhesion, and moisture absorption, was investigated.
- PDGA release kinetics from different hydrophilic bases (sodium carboxymethyl-cellulose and sodium alginate) were analyzed.
Main Results:
- A phytofilm formulation based on sodium alginate with 30.4% moisture content exhibited superior adhesion strength.
- Sodium alginate and sodium carboxymethyl-cellulose were identified as optimal hydrophilic bases for PDGA release, with release rates of 78.65% and 69.2%, respectively.
- A casting method was developed for manufacturing PDGA-containing phytofilms with a proposed shelf-life of 2 years.
Conclusions:
- Biosoluble phytofilms based on PDGA and sodium alginate represent a viable and effective option for burn treatment.
- The developed manufacturing technology and formulation ensure optimal film properties, including adhesion and moisture absorption.
- PDGA-containing phytofilms offer a natural, less toxic alternative with significant therapeutic potential for wound healing.
