MEDICATIONS FOR ERADICATION OF HELICOBACTER PYLORI (REVIEW)

Area of Science:

• Microbiology
• Pharmacology
• Drug Delivery Systems

Background:

• Helicobacter pylori infection is linked to gastritis, peptic ulcers, and gastric cancer.
• Standard eradication regimens often fail, necessitating novel therapeutic strategies.
• Plant-derived compounds show promise for inhibiting H. pylori growth.

Purpose of the Study:

• To explore alternative H. pylori eradication strategies using natural compounds.
• To investigate the potential of advanced drug delivery systems for local and prolonged H. pylori treatment.
• To evaluate foam-based systems for their efficacy in delivering therapeutic agents against H. pylori.

Main Methods:

• Review of scientific literature on plant-derived substances with antimicrobial activity against H. pylori.
• Analysis of foam systems as a drug delivery platform for gastrointestinal applications.
• Assessment of foam properties like mucoadhesion, swelling, and drug release kinetics.

Main Results:

• Plant-derived peptides, polyphenols, terpenes, and fatty acids exhibit inhibitory effects on H. pylori.
• Foam systems offer advantages such as large surface area, high bioavailability, and rapid therapeutic effect.
• Foam formulations can provide sustained drug concentrations for up to 4 hours, enhancing local action.

Conclusions:

• Plant-based compounds represent a viable alternative for H. pylori treatment.
• Foam drug delivery systems are suitable for local, prolonged action against H. pylori in the stomach and duodenum.
• Further development of these systems could lead to more effective H. pylori eradication therapies.