РАЗРАБОТКА РЕЦЕПТУРЫ И ТЕХНОЛОГИИ ПЕНООБРАЗОВАТЕЛЯ ИЗ МАСТИЧНОЙ (PISTACIA LENTISCUS L.) КАМЕДИ

Area of Science:

• Pharmacology
• Pharmaceutics
• Natural Products Chemistry

Background:

• Mastic gum (Pistacia lentiscus L.) exhibits bactericidal properties against Helicobacter pylori.
• Poor solubility and low biological penetration limit Mastic gum's therapeutic potential for H. pylori infections.
• Developing advanced drug delivery systems is crucial to overcome these limitations and improve gastric epithelial barrier penetration.

Purpose of the Study:

• To formulate and develop an innovative Mastic gum-based medicinal form with enhanced penetration.
• To create a foaming capsule system for improved delivery of Mastic gum to the stomach.
• To address the challenge of low bioavailability associated with Mastic gum's therapeutic properties.

Main Methods:

• Formulation development based on biopharmaceutical studies.
• Incorporation of Mastic gum into a foaming powder composition within capsules.
• Evaluation of foam-forming ability and stability in artificial gastric juice.

Main Results:

• A specific formulation for Mastic gum foaming powder capsules was determined.
• The technology for preparing these foaming capsules was successfully developed.
• The developed Mastic gum foaming capsules demonstrated satisfactory foam-forming ability and stability in simulated gastric conditions.

Conclusions:

• Innovative foaming capsules offer a promising approach for enhanced Mastic gum delivery.
• This formulation has the potential to improve the treatment efficacy of H. pylori infections.
• The developed technology meets standard requirements for foam systems, paving the way for clinical application.