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Published on: May 26, 2015
[Stroke prevention in patients with atrial fibrillation]
Gaia Sirimarco1, Lorenz Hirt1, Roman Sztajzel2
1Stroke Center, Service de neurologie, Département des neurosciences cliniques, CHUV et Université de Lausanne, 1011 Lausanne.
Abstract:
Oral anticoagulation with vitamin K antagonists (VKA) was the cornerstone of stroke prevention in atrial fibrillation (AF). This review article presents the state of the art, with regard to the treatment options developed over the past few years, the new oral anticoagulants (NOAC). A search in PubMed for relevant published studies has been performed. Dabigatran and apixaban were superior to warfarin to reduce stroke risk or systemic embolism ; dabigatran, rivaroxaban and edoxaban were non-inferior. All NOAC are globally non-inferior to warfarin for stroke prevention in non-valvular AF and they have a superior safety profile, with a reduced intracranial bleeding risk. They are now the first choice for treatment.
