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Related Concept Videos

Aging01:26

Aging

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
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The Effect of Aging on Tissues01:19

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Mitochondria01:37

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Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
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Non-human primates as a model for aging.

Ricki J Colman1

  • 1Department of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, Wisconsin Institutes for Medical Research, 1111 Highland Avenue, Madison, WI 53705, USA; Wisconsin National Primate Research Center, University of Wisconsin, 1220 Capitol Court, Madison, WI 53715, USA.

Biochimica Et Biophysica Acta. Molecular Basis of Disease
|July 22, 2017
PubMed
Summary
This summary is machine-generated.

Non-human primates, like macaques and marmosets, are superior animal models for aging research compared to mice. Their biological similarity to humans aids in understanding aging and developing therapies for age-related diseases.

Keywords:
AgingAnimal modelCommon marmosetNon-human primateRhesus monkey

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Area of Science:

  • Gerontology and Biomedical Research
  • Comparative Biology and Aging
  • Primate Models in Disease Research

Background:

  • Global population aging necessitates research into aging biology and age-related diseases.
  • Animal models are crucial for studying aging due to ethical and practical limitations in human research.
  • Mice are common but often inadequate models for human aging complexities.

Purpose of the Study:

  • To evaluate the suitability of non-human primates as aging research models.
  • To compare the utility of rhesus macaques and common marmosets in aging studies.
  • To highlight the potential of transgenic marmosets for modeling age-related diseases.

Main Methods:

  • Review of existing aging research methodologies utilizing non-human primates.
  • Comparative analysis of physiological and disease progression similarities between primates and humans.
  • Assessment of the common marmoset as a novel, smaller primate aging model.

Main Results:

  • Non-human primates, particularly rhesus macaques, closely mimic human aging processes and diseases.
  • Common marmosets offer a promising alternative with a shorter lifespan and potential for genetic modification.
  • Transgenic marmoset models enhance their utility for studying specific age-related conditions.

Conclusions:

  • Non-human primates provide more relevant models for human aging research than traditional mouse models.
  • The common marmoset is an emerging valuable model for aging and age-related disease research.
  • NIH-supported resources can help overcome limitations associated with using non-human primates in research.