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Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis
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Multimodal exercise training in multiple sclerosis: A randomized controlled trial in persons with substantial

Brian M Sandroff1, Rachel E Bollaert2, Lara A Pilutti3

  • 1University of Alabama at Birmingham, Department of Physical Therapy, United States.

Contemporary Clinical Trials
|July 23, 2017
PubMed
Summary

Multimodal exercise training significantly improved walking endurance and cognitive speed in individuals with multiple sclerosis (MS) and mobility disability. This approach offers a promising rehabilitation strategy for MS patients experiencing functional decline.

Keywords:
CognitionDisabilityExerciseMobilityMultiple sclerosisPhysical fitness

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Area of Science:

  • Neurology
  • Rehabilitation Medicine
  • Exercise Science

Background:

  • Mobility disability is a common and disabling symptom of multiple sclerosis (MS).
  • Previous exercise interventions in MS have not consistently targeted individuals with established mobility decline.
  • Exercise training is a potential strategy to mitigate MS-related mobility impairments.

Purpose of the Study:

  • To evaluate the efficacy of supervised, multimodal exercise training versus an active control in individuals with substantial MS-related mobility disability.
  • To assess the impact of exercise on mobility, gait, physical fitness, and cognitive function in this population.

Main Methods:

  • A multi-site randomized controlled trial (RCT) involving 83 participants with significant MS-related mobility disability.
  • Participants were assigned to either 6 months of supervised multimodal exercise (aerobic, resistance, balance) or a stretching/toning control group.
  • Assessments of mobility, gait, fitness, and cognitive processing speed were conducted at baseline, midpoint, and post-intervention.

Main Results:

  • The exercise intervention group showed statistically significant improvements in six-minute walk performance and peak power output compared to the control group.
  • Cognitive processing speed, measured by the Paced Auditory Serial Addition Test, also significantly improved in the intervention group.
  • No significant improvements were observed in gait outcomes for the exercise group compared to the control group.

Conclusions:

  • Multimodal exercise training demonstrates preliminary evidence of improving endurance walking and cognitive processing speed in individuals with MS and substantial mobility disability.
  • These findings suggest that exercise interventions targeting cardiorespiratory capacity may benefit this MS subgroup.
  • The results support the development of larger, multi-site exercise rehabilitation programs for persons with MS-related mobility disability.