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Immunoglobulin-G4 related mastitis: A case report.
Ee Syn Tan1, Brendon Friesen2, Seow Foong Loh3
1Department of General Surgery (Monash Health), 135-145 David Street, Dandenong, VIC 3175, Australia.
International Journal of Surgery Case Reports
|July 24, 2017
Summary
IgG4-related mastitis (IgG4-RM) is a rare condition, often presenting as a breast lump. Diagnosis requires histology, and it typically has a good prognosis with treatment.
Area of Science:
- Immunology
- Pathology
- Oncology
Background:
- IgG4-related mastitis (IgG4-RM) is an exceptionally rare condition, with limited reported cases.
- IgG4-related disease (IgG4-RD) shares characteristic histopathological features across affected organs, including dense lymphocytic infiltration, storiform fibrosis, and obliterative phlebitis.
Purpose of the Study:
- To present a case of incidentally discovered IgG4-related mastitis in a 52-year-old woman during routine breast screening.
- To review and explore the existing literature on IgG4-related mastitis and IgG4-related disease.
Main Methods:
- Case report presentation.
- Literature review of IgG4-related mastitis and IgG4-related disease.
Main Results:
- IgG4-RM was incidentally found during a routine breast screening.
- Literature indicates IgG4-RM often manifests as a painless breast lump, potentially with systemic symptoms.
- IgG4-RM is generally considered benign with a favorable prognosis following steroid treatment or surgical excision.
Conclusions:
- IgG4-related mastitis and IgG4-related disease are emerging medical entities with unclear etiology.
- Histological analysis is crucial for diagnosing IgG4-RM, as distinguishing it from malignant breast lesions based on clinical or imaging data is challenging.
- Increased clinical awareness of IgG4-RM can improve patient management; extensive whole-body imaging is not routinely recommended unless symptoms are present.
