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Decreased Hepatitis B vaccine response in pediatric patients with atopic dermatitis, psoriasis, and morphea

Deepa P Patel1, James R Treat2, Leslie Castelo-Socio2

  • 1Section of Pediatric Dermatology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, United States; The University of Louisville School of Medicine, Louisville, Kentucky 40206, United States.

Vaccine
|July 25, 2017
PubMed

Insights

Patients with psoriasis, atopic dermatitis, or morphea may not respond well to the Hepatitis B vaccine. This study assessed antibody response rates before immunosuppressive therapy to identify at-risk groups.

Area of Science:

  • Immunology
  • Vaccinology
  • Dermatology

Background:

  • Certain patient groups, including those with HIV, inflammatory bowel disease, and chronic kidney disease, exhibit high rates of non-response to the Hepatitis B vaccine.
  • These populations face elevated infection risks due to their conditions and immunosuppressive medications.
  • Identifying non-responder groups is crucial for developing effective vaccination strategies and preventing severe infections.

Purpose of the Study:

  • To determine the antibody response rate to the Hepatitis B vaccine in patients diagnosed with psoriasis, atopic dermatitis, or morphea.
  • To evaluate these response rates specifically before the initiation of immunosuppressive therapy.

Main Methods:

  • Prospective assessment of antibody response to Hepatitis B vaccine.
  • Inclusion of patients with psoriasis, atopic dermatitis, or morphea.
  • Evaluation conducted prior to the commencement of immunosuppressive drug treatment.

Main Results:

  • Data on antibody response rates in the studied dermatological conditions are presented.
  • Analysis focuses on the proportion of patients achieving protective antibody levels post-vaccination.

Conclusions:

  • The study provides essential data on Hepatitis B vaccine immunogenicity in specific dermatological patient cohorts.
  • Findings will inform clinical practice regarding vaccination guidelines for these susceptible populations.

Keywords:
Atopic dermatitisHepatitis B vaccineMorpheaNonrespondersPsoriasis

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