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[Recurrent respiratory papillomatosis in a pediatric patient: case report]

Felipe M Benavente1, Marcelo Contreras2, Giancarlo Perferi3

  • 1Laboratorio de Inmunodeficiencias Primarias, Centro Jeffrey Modell para Diagnóstico de Inmunodeficiencias Primarias, Centro de Excelencia en Medicina Traslacional, Facultad de Medicina, Universidad de La Frontera, Temuco, Chile.

Revista Chilena De Pediatria
|July 25, 2017
PubMed

Insights

Genetic factors influencing the immune system may impact human papillomavirus (HPV) diseases. This case study highlights specific Human Leukocyte Antigen (HLA) alleles in a child with recurrent respiratory papillomatosis.

Area of Science:

  • Immunogenetics
  • Viral Pathogenesis
  • Pediatric Otolaryngology

Background:

  • Host immune system genetic variability is a key factor in human papillomavirus (HPV) disease development.
  • Recurrent Respiratory Papillomatosis (RRP) is a rare HPV-related condition affecting the airway.

Observation:

  • A 5-year-old child presented with chronic laryngeal papillomatosis, likely acquired vertically.
  • Diagnosis was confirmed via biopsy, identifying HPV-6.
  • The child exhibited homozygous HLA alleles: DQA1*0505, DQB1*0301, and DRB1*1101.

Findings:

  • The case details the genetic profile of a pediatric patient with severe laryngeal papillomatosis.
  • Specific Human Leukocyte Antigen (HLA) alleles were identified in association with HPV-6 infection.

Implications:

  • Further research is required to determine prevalent HLA alleles in the Latino population.
  • Understanding HLA associations could reveal genetic susceptibilities to RRP.

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