Related Experiment Video

Updated: Feb 26, 2026

Isolation and Physiological Analysis of Mouse Cardiomyocytes
11:02

Isolation and Physiological Analysis of Mouse Cardiomyocytes

Published on: September 7, 2014

24.0K

Hyperthyroidism and the Heart

Patricia Mejia Osuna1, Maja Udovcic1, Morali D Sharma1

  • 1Houston Methodist Hospital, Houston, Texas.

Methodist Debakey Cardiovascular Journal
|July 26, 2017
PubMed

Insights

Excess thyroid hormone significantly impacts heart function, potentially causing heart failure and dilated cardiomyopathy. This review explores hyperthyroidism

Area of Science:

  • Cardiology
  • Endocrinology
  • Molecular Biology

Background:

  • Thyroid hormones are crucial regulators of cardiac function and structure.
  • Imbalances in thyroid hormone levels can lead to significant cardiovascular complications.

Purpose of the Study:

  • To review the cardiovascular pathophysiology and molecular mechanisms of hyperthyroidism.
  • To examine the cardiac complications associated with excess thyroid hormone.

Main Methods:

  • Literature review of studies on thyroid hormone and cardiovascular effects.
  • Analysis of molecular pathways involved in hyperthyroid cardiomyopathy.
  • Examination of clinical outcomes in hyperthyroid patients.

Main Results:

  • Hyperthyroidism alters cardiovascular hemodynamics, increasing cardiac output.
  • Prolonged excess thyroid hormone can result in high-output heart failure.
  • Dilated cardiomyopathy is a potential late-stage complication of untreated hyperthyroidism.

Conclusions:

  • Hyperthyroidism poses significant risks to cardiovascular health.
  • Understanding the molecular basis of thyroid-induced heart disease is vital for management.
  • Early diagnosis and treatment of hyperthyroidism can prevent severe cardiac complications like heart failure and atrial fibrillation.

Keywords:
atrial fibrillationheart failurehyperthyroidismsubclinical hyperthyroidism

More Related Videos

Rodent Working Heart Model for the Study of Myocardial Performance and Oxygen Consumption12:43

Rodent Working Heart Model for the Study of Myocardial Performance and Oxygen Consumption

Published on: August 16, 2016

21.0K
Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model04:14

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model

Published on: October 6, 2023

1.3K

Related Concept Videos

Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
5.9K
Increased pulse rate01:17

Increased pulse rate

Tachycardia is a condition marked by an abnormally fast or irregular heart rate, surpassing the typical resting rate. In adults, tachycardia is characterized by a pulse rate ranging from 100 to 180 beats per minute. The increased heart rate can result in inadequate blood flow to various body parts, ultimately diminishing the oxygen supply to organs and tissues.
Many factors can elevate the risk of developing tachycardia. These include advanced age, a family history of arrhythmias, and an...
1.2K
Heart Failure I: Introduction01:27

Heart Failure I: Introduction

Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
1.0K
Cardiac Output I:Effect of Heart Rate on Cardiac Output01:19

Cardiac Output I:Effect of Heart Rate on Cardiac Output

Cardiac Output
Cardiac output (CO) refers to the total amount of blood ejected by one of the ventricles in liters per minute (L/min). In a resting adult, CO ranges from 5 to 6 L/min, adjusting according to the body's metabolic requirements.
Effect of Heart Rate on Cardiac Output
Cardiac output adapts to metabolic demands during stress, physical activity, or illness. The autonomic nervous system regulates heart rate via the sinoatrial node. The parasympathetic nervous system decreases heart...
2.9K
Factors Influencing Heart Rate01:30

Factors Influencing Heart Rate

The heart rate, or pulse rate, is a vital indicator of cardiovascular health. It reflects the number of times the heart beats per minute. Various physiological and environmental factors influence heart rate, increasing or decreasing cardiac output. Understanding these factors is crucial for assessing heart function and identifying potential health issues.
Let us explore the significant factors affecting heart rate, including age, body temperature, posture, acute pain, chemical influences,...
7.0K
Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
8.3K