Related Experiment Video
Updated: Feb 25, 2026
04:53
Author Spotlight: Traditional Chinese Medicine for Sleep Disorders in Acute COPD — A Safe, Cost-Effective Approach
Published on: October 18, 2024
1.5K
Relationship between IL-1β polymorphisms and obstructive sleep apnea syndrome.
1Department of Repiratory Medicine, Zhejiang Hospital Hangzhou, Zhejiang Province, PR China. fy39sj@163.com.
European Review for Medical and Pharmacological Sciences
|July 26, 2017
Summary
Interleukin-1 beta (IL-1β) gene polymorphisms at loci 154 and 468 are linked to obstructive sleep apnea syndrome (OSAS). These genetic variations may influence IL-1β protein levels, potentially contributing to OSAS development.
Area of Science:
- Genetics
- Sleep Medicine
- Immunology
Background:
- Obstructive sleep apnea syndrome (OSAS) is a prevalent sleep disorder.
- The role of genetic factors, specifically interleukin-1 beta (IL-1β) gene polymorphisms, in OSAS pathogenesis requires further investigation.
Purpose of the Study:
- To investigate the association between IL-1β gene polymorphisms and the risk of developing OSAS.
- To examine the impact of these polymorphisms on IL-1β expression levels.
Main Methods:
- Case-control study involving 164 OSAS patients and 146 healthy controls.
- Restriction Fragment Length Polymorphism (RFLP) used to analyze IL-1β gene polymorphisms at loci 154 and 468.
- Quantitative fluorescence PCR, ELISA, and Western blot assays employed to measure IL-1β mRNA and protein expression.
Main Results:
- Higher frequencies of G/G and C/C genotypes at IL-1β locus 154 were observed in OSAS patients compared to controls.
- Increased frequencies of T/A and T/T genotypes at IL-1β locus 468 were found in OSAS patients.
- Lower IL-1β protein levels were associated with G/G and C/C genotypes at locus 154, and T/T genotypes at locus 468, despite no significant differences in mRNA expression.
Conclusions:
- IL-1β gene polymorphisms at loci 154 and 468 are associated with an increased incidence of OSAS.
- These genetic variations may contribute to OSAS by modulating IL-1β protein expression levels.
More Related Videos
Related Concept Videos
01:21Sleep Apnea
629
Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
The condition is more prevalent among...
629
01:11Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase
51
Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
51
01:29Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu
57
Genetic variations significantly influence drug response through pharmacokinetics, receptor interactions, and biologic milieu modifications. Pharmacokinetic alterations impact drug metabolism and clearance, affecting efficacy and toxicity. Variants in drug-metabolizing enzymes, such as CYP2C9 and CYP2C19, alter drug activation and elimination. For example, CYP2C9 loss-of-function variants require lower warfarin doses to prevent excessive bleeding, while CYP2C19 variants reduce clopidogrel...
57
01:17Other Pulmonary Disorders
1.7K
Respiratory disorders encompass a range of conditions with varying levels of severity. Asthma, marked by chronic airway inflammation and hypersensitivity, is one such condition. It can lead to airway obstruction due to factors like bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Asthma triggers are diverse, ranging from allergens to emotional upset, and treatment focuses on both immediate relief through bronchodilators and long-term inflammation suppression.
1.7K
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
4.9K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
4.9K
01:05Single Nucleotide Polymorphisms-SNPs
18.8K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
18.8K