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Updated: Feb 25, 2026

Cortical Bone Assessment Using Ultrasonic Guided Waves: A Reproducibility Study in a Healthy Population
Published on: January 31, 2025
[New methods for the evaluation of bone quality. The importance of assessing bone quality.]
Mika Yamauchi1, Toshitsugu Sugimoto1
1Internal Medicine 1, Shimane University Faculty of Medicine, Japan.
Abstract:
Fracture risk in patients with secondary osteoporosis, which includes glucocorticoid-induced osteoporosis, was found to be higher than the fracture risk predicted by decreased bone mineral density. Moreover, a large scale randomized clinical study also found that an increased bone mineral density was not a strong predictor of the effectiveness of anti-resorptive agents in preventing fractures. The accumulation of such evidence has led us to conclude that an explanatory factor of bone strength other than bone mineral density must be bone quality. The development of a new method for assessment of bone quality is imperative to more efficiently i)identify patients at high risk of fracture, ii)determine drug selection and assess drug effectiveness, and iii)decide on drug continuation, discontinuation, or changes.
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