[New methods for the evaluation of bone quality. Assessments of bone quality from bone tissues.]

Indeed DXA and quantitative CT both which measure bone mineral amount are well established methods to predict bone volume, but some clinical studies say that different rates of bone turnover can cause discrepancies between bone mineral density and bone volume. Bone strength is accused to not only bone mineral density but bone quality, and developments of the osteoporosis drugs have made "bone quality" more important in explaining bone strength. Bone quality refers to architecture, turnover, damage accumulation and mineralization. Turnover and microdamage at bone tissue are evaluated only by bone histomorphometry, with which it becomes possible to assess bone quality from bone tissue combination with micro-CT and vibrational spectroscopy.