Related Experiment Video
Updated: Aug 11, 2026

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation
Published on: January 26, 2016
Peptides Selected Using Phage Library Variants, Effectively Inhibit Trypanosoma cruzi Infection
Yu E Kleshchenko1, A V Zhigunova2, M V Dalin2
1Department of Microbiology and Virology, Medical Institute, Peopleэs Friendship University of Russia, Moscow, Russia. ykleschenko@gmail.com.
Abstract:
Four peptide sequences characterized by high content of hydrophobic, charged, and polar amino acids were obtained from 23 clones of M13 phage. Peptides P2 and P4 exhibited highest binding affinity for immobilized trypomastigotes. The inhibitory effects of peptides seemed to be due to blockade of certain epitopes on T. cruzi surface proteins responsible for interactions with the respective receptors of host cells.
More Related Videos
08:31Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions
Published on: December 1, 2020
08:48In Vitro Drug Screening Against All Life Cycle Stages of Trypanosoma cruzi Using Parasites Expressing β-galactosidase
Published on: November 5, 2021
Related Concept Videos
American Trypanosomiasis
Antiprotozoal Agents