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Published on: January 21, 2020
Is periodontitis associated with halitosis? A systematic review and meta-regression analysis
Manuela F Silva1, Mariana G Cademartori1, Fábio R M Leite1,2
1Graduate Program in Dentistry, Federal University of Pelotas, Pelotas, Brazil.
Aim:
To systematically review the literature in order to investigate a potential association between periodontitis and halitosis.
Methods:
Electronic searches were performed in four different databases: PubMed, Scopus, Web of Science and Scielo. Population-based observational studies that tested the association between periodontitis and halitosis were included. Additionally, meta-analysis, meta-regression and subgroup analyses were performed to synthesize the evidence.
Results:
A total of 1,107 articles were identified in electronic searches; out of which, five were included within the meta-analysis. Pooled estimates revealed that individuals with periodontitis presented 3.16 times higher odds (OR 3.16; 95% CI: 1.12-8.95) of having halitosis. Meta-regression and subgroups analyses showed that criteria used for halitosis and periodontitis assessment explained nearly 45% and 24% of heterogeneity between studies, respectively.
Conclusions:
Positive association between periodontitis and halitosis was found in pooled results of population-based observational studies. However, this evidence is derived from cross-sectional studies.
