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Updated: Feb 25, 2026

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G-Quadruplexes: Prediction, Characterization, and Biological Application.

Chun Kit Kwok1, Catherine J Merrick2

  • 1Department of Chemistry, City University of Hong Kong, Kowloon Tong, Hong Kong SAR, China.

Trends in Biotechnology
|July 31, 2017
PubMed
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This summary is machine-generated.

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Guanine-rich sequences form G-quadruplex structures. Advanced methods now reveal their diverse structures and functions, enabling new biological applications.

Area of Science:

  • Biochemistry and Molecular Biology
  • Genetics and Genomics
  • Structural Biology

Background:

  • Guanine (G)-rich sequences in nucleic acids can form G-quadruplex structures.
  • These structures are characterized by G-quartets linked by loop nucleotides.
  • The structural and topological diversity of G-quadruplexes has been a focus of research for decades.

Purpose of the Study:

  • To review recent methodological advances in G-quadruplex identification and characterization.
  • To highlight the expanded understanding of G-quadruplex structure and function.
  • To showcase how new findings and methods open avenues for G-quadruplex applications in biosciences.

Main Methods:

  • Recent methodological advances facilitate high-resolution and high-throughput identification and characterization of G-quadruplexes.
Keywords:
G-quadruplexaptamerbiosensingcell imagingnext-generation sequencingnucleic acid structure

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  • In vivo and in vitro studies are employed to investigate G-quadruplexes.
  • Development of molecular and chemical tools based on G-quadruplex structural properties.

    • Main Results:

    • Methodological advances have significantly improved the identification and characterization of G-quadruplexes.
    • Our understanding of G-quadruplex structure and function has been greatly expanded.
    • Knowledge of structural properties aids in designing molecular and chemical tools.

    Conclusions:

    • Exciting new methods and findings provide novel insights into G-quadruplexes.
    • These advancements open new doors for investigating G-quadruplex functions and applications.
    • G-quadruplex research holds significant potential for basic and applied biosciences.