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The power of the few
Ran Chen1, Yuan Pan1, David H Gutmann1
1Department of Neurology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Genes & Development
|August 3, 2017
Summary
Glioblastoma, a complex brain cancer, involves diverse cells. A specific subpopulation with mutant epidermal growth factor receptor (EGFRvIII) supports other tumor cells and evades targeted therapies.
Area of Science:
- Oncology
- Cancer Biology
- Neuro-oncology
Background:
- Malignant brain cancers like glioblastoma are complex ecological systems.
- Understanding cellular and acellular components is crucial for effective glioblastoma therapy design.
Purpose of the Study:
- To investigate the role of specific glioblastoma cell subpopulations in tumor survival and therapy evasion.
- To elucidate the function of mutant epidermal growth factor receptor (EGFRvIII) expressing cells.
Main Methods:
- Analysis of glioblastoma cell subpopulations.
- Investigating the role of EGFRvIII expression in tumor cell survival.
- Assessing mechanisms of therapy evasion.
Main Results:
- A subpopulation of glioblastoma cells expressing mutant EGFRvIII promotes the survival of non-EGFRvIII-expressing tumor cells.
- EGFRvIII-expressing cells contribute to the evasion of molecularly targeted therapies.
Conclusions:
- EGFRvIII-expressing glioblastoma cells play a critical role in maintaining tumor viability and resistance.
- Targeting EGFRvIII may offer a strategy to overcome therapy resistance in glioblastoma.
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