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Updated: Feb 25, 2026

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation
Published on: January 16, 2019
How Does Genetics Influence the Efficacy and Safety of Antiarrhythmic Drugs?
1Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Vanderbilt University School of Medicine, Room 559 Preston Research Building, 2220 Pierce Avenue, Nashville, TN 37232-6602, USA.
Abstract:
Recent progress in genomic sequencing has begun to elucidate the basic mechanisms for several adverse responses, as well as the clinical efficacy, for antiarrhythmic drugs. DNA variants in drug metabolizing enzymes have been implicated in excessive drug accumulation, and genetic variability in drug targets can identify individuals at increased risk for serious side effects, in particular proarrhythmia. It is hoped that future advances in the area of genomic medicine will lead to more individually tailored or personalized pharmacologic therapy in the management of cardiac arrhythmias.
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