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Alendronate Functionalized Mesoporous Bioactive Glass Nanospheres.
Elisa Boanini1, Silvia Panseri2, Fabiola Arroyo3
1Department of Chemistry "G. Ciamician", University of Bologna, Via Selmi 2, Bologna 40126, Italy. elisa.boanini@unibo.it.
Materials (Basel, Switzerland)
|August 5, 2017
Summary
Mesoporous bioactive glass nanospheres effectively load alendronate for targeted drug delivery. This functionalized material shows potential for inhibiting osteoclast activity and reducing tumor cell viability.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Drug Delivery Systems
Background:
- Mesoporous bioactive glasses (MBG) offer high surface area for drug encapsulation.
- Alendronate (AL) is a potent bisphosphonate used to treat bone diseases.
- Developing effective delivery systems for alendronate is crucial for localized treatment.
Purpose of the Study:
- To synthesize and characterize mesoporous bioactive glass nanospheres (nMBG) for alendronate loading.
- To evaluate the in vitro efficacy of alendronate-loaded nMBG against cancer and osteoclast cells.
- To explore the potential of nMBG as a substrate for modulated alendronate delivery.
Main Methods:
- Synthesis of mesoporous bioactive glass nanospheres (nMBG).
- Loading of alendronate (AL) onto nMBG with varying concentrations (up to 17 wt%).
- In vitro assessment using human osteosarcoma (MG63) and murine macrophage (RAW 264.7) cell lines.
Main Results:
- nMBG characterized by high surface area (528 m²/g) and pore volume (0.63 cm³/g), decreasing with higher AL content.
- Alendronate loading was successfully modulated up to 17 wt%.
- In vitro studies showed decreased tumor cell viability and dose-dependent inhibition of osteoclast activity by AL-loaded nMBG.
Conclusions:
- Mesoporous bioactive glass nanospheres are suitable supports for local alendronate delivery.
- The antiresorptive and antitumor properties of functionalized nMBG can be tuned by adjusting alendronate loading.
- This approach offers potential for localized treatment of bone-related pathologies.
