Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Guidelines for Comparing Circular Dichroism Spectroscopy and Molecular Dynamics Simulations for Biomolecules.

Chemphyschem : a European journal of chemical physics and physical chemistry·2026
Same author

Improved in vivo bone regeneration and mechanical stability in critical-sized defects using WZM211 fluorine coated fibres.

Acta biomaterialia·2026
Same author

Species-Specific Chondrogenesis in Growth Factor-Free Hydrogels: Translational Lessons from Ovine and Human MSCs.

Stem cell reviews and reports·2026
Same author

An overview of reliable and representative DVC measurements for musculoskeletal tissues.

Journal of microscopy·2025
Same author

Influence of Cell Seeding Density and Material Stiffness on Chondrogenesis of Human Stem Cells Within Soft Hydrogels, Without the Use of Exogenous Growth Factors.

Gels (Basel, Switzerland)·2025
Same author

Multi-material 3D printed composites inspired by nacre: a hard/soft mechanical interplay.

Scientific reports·2025
Same journal

Correction: Yang et al. Microstructural Characteristics of High-Pressure Die Casting with High Strength-Ductility Synergy Properties: A Review. <i>Materials</i> 2023, <i>16</i>, 1954.

Materials (Basel, Switzerland)·2026
Same journal

Effect of La and Ce Microalloying on the Corrosion Resistance of 0.4Sb Low-Alloy Steel in a Harsh Marine Atmospheric Environment.

Materials (Basel, Switzerland)·2026
Same journal

High-Temperature Properties of Magnesium Ammonium Phosphate Cement Modified with Gold Tailings.

Materials (Basel, Switzerland)·2026
Same journal

A Study on the Evolution of Intermetallic Phase Microstructure and High-Temperature Creep Behavior in Mg-8.0Al-1.0Nd-1.5Gd-Mn Alloys.

Materials (Basel, Switzerland)·2026
Same journal

Material-Driven Clinical Complications in Mechanical Circulatory Support: From Blood-Material Interactions to Device-Related Adverse Events.

Materials (Basel, Switzerland)·2026
Same journal

Influence of Final Irrigation on Calcium Silicate-Based Sealer Dentinal Tubular Penetration: A Systematic Review.

Materials (Basel, Switzerland)·2026
See all related articles

Related Experiment Video

Updated: Feb 25, 2026

Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration
06:05

Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration

Published on: July 14, 2023

1.7K

Composite Hydrogels for Bone Regeneration.

Gianluca Tozzi1, Arianna De Mori2, Antero Oliveira3

  • 1School of Engineering, University of Portsmouth, Anglesea Building, Anglesea Road, Portsmouth PO1 3DJ, UK. gianluca.tozzi@port.ac.uk.

Materials (Basel, Switzerland)
|August 5, 2017
PubMed
Summary
This summary is machine-generated.

Novel hydrogels offer promising solutions for bone fracture regeneration, addressing the growing burden of osteoporosis. This review details strategies for optimizing hydrogels for enhanced mechanical strength and controlled drug delivery in tissue engineering applications.

Keywords:
biomaterialsbisphosphonatesbone regenerationgrowth factorshydrogelshydroxyapatitemechanical propertiesregenerative medicinestatinstissue engineering

More Related Videos

Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs
10:19

Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs

Published on: August 8, 2022

2.5K
Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
09:35

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

10.1K

Related Experiment Videos

Last Updated: Feb 25, 2026

Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration
06:05

Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration

Published on: July 14, 2023

1.7K
Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs
10:19

Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs

Published on: August 8, 2022

2.5K
Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
09:35

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

10.1K

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Orthopedic Research

Background:

  • Bone-related disorders, particularly osteoporosis, are increasing globally, leading to a significant burden of bone fractures.
  • Osteoporosis affects millions, with numbers projected to rise due to an aging population.
  • Effective bone fracture regeneration strategies are crucial, driving the development of novel biomaterials.

Purpose of the Study:

  • To review strategies for formulating hydrogels with ideal properties for bone regeneration.
  • To discuss advancements in improving hydrogel mechanical competence.
  • To explore controlled delivery of drugs and growth factors using hydrogels for tissue engineering.

Main Methods:

  • Literature review focusing on hydrogel formulation for bone regeneration.
  • Analysis of strategies for enhancing hydrogel mechanical properties.
  • Examination of controlled release systems for therapeutic agents within hydrogels.

Main Results:

  • Hydrogels are highly adaptable biomaterials for tissue engineering (TE) applications.
  • Chemical modifications allow tailoring of hydrogel properties for specific bone regeneration needs.
  • Key areas of focus include mechanical strength and the controlled delivery of bioactive molecules.

Conclusions:

  • Hydrogels represent a promising class of biomaterials for bone regeneration.
  • Optimizing mechanical properties and controlled delivery are critical for successful TE applications.
  • Further research in hydrogel development can significantly advance bone fracture treatment.