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Related Concept Videos

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

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In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
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Acute Kidney Injury III: Clinical Manifestations01:29

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Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
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Acute Pancreatitis II: Clinical Manifestations and Management01:30

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Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
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Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow01:26

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Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug...
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Acute Pancreatitis I: Introduction01:27

Acute Pancreatitis I: Introduction

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Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
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Acute Kidney Injury I: Introduction01:22

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Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
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Updated: Feb 25, 2026

Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen
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SUBACUTE HEPATIC FAILURE-A CLINICAL PROFILE.

H S Pruthi1, A C Anand2, Balwinder Singh3

  • 1Associate Professor. Medicine and Gastroenterology, Armed Forces Medical College, Pune-40.

Medical Journal, Armed Forces India
|August 5, 2017
PubMed
Summary
This summary is machine-generated.

Subacute hepatic failure is a serious condition affecting mostly middle-aged males, presenting with jaundice and ascites. This potentially fatal liver disease has a high mortality rate, highlighting the need for urgent medical attention.

Keywords:
HBsAgJaundiceSubacute hepatic failure

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Area of Science:

  • Hepatology
  • Gastroenterology
  • Internal Medicine

Background:

  • Subacute hepatic failure (SHF) is a critical condition with significant mortality.
  • Understanding the clinical presentation and outcomes of SHF is crucial for timely intervention.

Purpose of the Study:

  • To analyze the clinical features, laboratory findings, complications, and outcomes of 37 patients with subacute hepatic failure.
  • To provide insights into the management and prognosis of this severe liver condition.

Main Methods:

  • A retrospective analysis of 37 cases of subacute hepatic failure.
  • Data collected from five major gastroenterology centers over a ten-year period.
  • Review of clinical presentation, laboratory results, complications, and mortality.

Main Results:

  • The majority of patients were males (65%) with a mean age of 38 years.
  • Common symptoms included jaundice (100%), exhaustion (78.3%), and pedal edema (78.3%).
  • Significant complications included renal failure (48.7%) and spontaneous bacterial peritonitis (43.2%), with a hospital mortality rate of 54%.

Conclusions:

  • Subacute hepatic failure is a potentially fatal condition with a high mortality rate.
  • Early recognition of clinical features and prompt management of complications are essential.
  • Hepatitis B surface antigen (HbsAg) was detected in 46% of cases, suggesting its role in the etiology.