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Related Concept Videos

Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

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Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
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Seizures: Classification01:13

Seizures: Classification

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Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
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Antiepileptic Drugs: Potassium Channel Activators01:20

Antiepileptic Drugs: Potassium Channel Activators

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Ezocgabine or retigabine, an antiepileptic drug of remarkable efficacy, has revolutionized the management of seizures. It is a potassium channel activator, explicitly targeting the family of Q subtype potassium channels. It enhances the transmembrane potassium currents, regulating neuronal excitability. This action stabilizes the resting membrane potential, a pivotal factor in mitigating the hyperexcitability that characterizes epilepsy.
Ezogabine has gained approval as an adjunctive treatment...
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Antiepileptic Drugs: Glutamate Antagonists01:14

Antiepileptic Drugs: Glutamate Antagonists

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Glutamate is a fundamental neurotransmitter in the central nervous system, playing a vital role in neuronal communication and various cognitive processes. Glutamate stands as the principal excitatory neurotransmitter in the brain. Its presence is crucial for the communication between neurons, underpinning essential processes such as synaptic transmission, neuronal excitability, and plasticity. These functions are vital for higher-order cognitive processes, including learning and memory. The...
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Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein01:20

Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein

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Antiepileptic drugs, such as levetiracetam (Keppra) and brivaracetam (Briviact), have emerged as crucial tools in managing epilepsy. These medications exert their therapeutic effects by targeting the synaptic vesicle protein SV2A, a transmembrane glycoprotein primarily found in the brain.
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...
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Antiepileptic Drugs: Calcium Channel Blockers01:17

Antiepileptic Drugs: Calcium Channel Blockers

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Calcium channel blockers, a class of antiepileptic drugs, regulate the flow of calcium ions within neurons.
Calcium channel blockers exert their antiepileptic effects by targeting T-type calcium channels, which are integral to transmitting nerve signals in the central nervous system. These channels allow the passage of calcium ions, which are vital for neuronal communication. By inhibiting T-type calcium channels, calcium channel blockers effectively reduce the release of neurotransmitters and...
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Manipulation of Epileptiform Electrocorticograms ECoGs and Sleep in Rats and Mice by Acupuncture
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Headache and Epilepsy.

Dong Wook Kim1, Sang Kun Lee2

  • 1Department of Neurology, Konkuk University School of Medicine, Seoul, Korea.

Journal of Epilepsy Research
|August 5, 2017
PubMed
Summary
This summary is machine-generated.

Migraine and epilepsy share genetic links and similar brain function disruptions. This review explores their connections, from symptoms to treatments, highlighting shared mechanisms and comorbidities.

Keywords:
EpidemiologyEpilepsyGeneticsHeadacheMigraineTreatment

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Electrophoretic Delivery of &#947;-aminobutyric Acid GABA into Epileptic Focus Prevents Seizures in Mice
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Area of Science:

  • Neurology
  • Neuroscience

Background:

  • Headache, particularly migraine, and epilepsy exhibit overlapping clinical features and are frequently comorbid.
  • Both conditions share genetic predispositions and common pathophysiological mechanisms, including imbalances in neural excitation and inhibition.

Purpose of the Study:

  • To review the multifaceted relationship between headache and epilepsy.
  • To discuss classification, clinical features, epidemiology, genetics, pathophysiology, and treatment strategies for both conditions.

Main Methods:

  • This is a review article, synthesizing existing literature on headache and epilepsy.
  • The review examines various aspects of the connection between these two neurological disorders.

Main Results:

  • Headache can be the sole symptom of an epileptic seizure and commonly occurs as preictal, ictal, or postictal symptom in epilepsy.
  • Migraine and epilepsy are highly comorbid, with several antiepileptic drugs demonstrating efficacy in treating both conditions.

Conclusions:

  • The close association between migraine and epilepsy warrants further investigation into their shared underlying mechanisms.
  • Understanding these connections can inform integrated treatment approaches for patients suffering from both headache and epilepsy.